What is Sepsis

The current meta-analysis was conducted to determine the predictors of acute respiratory distress syndrome (ARDS) in patients with sepsis.

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A better understanding of equine sepsis to lead to new therapeutic approaches and even improve prevention of the devastating disease in humans and horses.

This would require the mobilization of equine veterinary care centers worldwide in order to include an adequate number of horses and to carry out multicenter studies. “So it would take five similar equine hospitals to perform a study of 300 cases in one year. Horses hospitalized in intensive care receive intravenous fluid and antibiotic therapy as seen in human medicine, which is not the case in current experimental models. A better understanding of the mechanisms associated with sepsis would allow for earlier and more appropriate management, they said. “Experimental data suggest that, like humans, they are much more susceptible to the effects of endotoxins. To obtain robust and reproducible results, such studies must rely on two levers. “Furthermore, like humans, and unlike experimental models, horses live in an environment rich in microbial exposure. In intensive care units, sepsis is the leading cause of death. The first would be to validate the definition of sepsis used in veterinary medicine, ideally developing one as closely aligned as possible to the definition used in human medicine. “Despite the differences between horses and humans, the spontaneous development of sepsis in horses, especially after gastrointestinal diseases, could be a lever to understand the pathophysiological mechanisms and for the search for biomarkers and therapeutic targets in large-scale studies.” Horses with sepsis show many of the signs observed in humans, with similar drivers that generates the dysfunctions that can lead to death. In their review, they provided an overview of the different animal species used to model human sepsis, then focused on adult equine sepsis as a spontaneous model of sepsis and its potential implications for human and veterinary medicine.